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This highlights the value of srom as a treatment option for medically ill, hospitalised patients with oud. In the current case series, we describe rapid srom titration in the outpatient setting for four individuals with severe opioid use disorder at high risk of overdose due to exposure to the toxic unregulated opioid supply locally. Srom starting doses should be based on the individuals opioid tolerance and risk of toxicity.
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Suggested ranges, which should be tailored to the individuals needs, are 3050 mg for people with low tolerance or high risk for toxicity, 100150 Consider a smaller reduction if risk of tolerance loss is low (e. g. , those who have continued using other opioids since last srom dose). Consider a more conservative dose adjustment schedule for individuals who have not used unregulated opioids since their last srom dose. Is essential for successful treatment outcomes, reducing the risk of unregulated opioid use, and mitigating any potential harm.
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Srom (i. e. , kadian@) is available for individuals with opioid use disorder (oud) for whom buprenorphine formulations have been ineffective, contraindicated, and/or refused. Rpho fentanyl time between doses
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