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Be very careful in challenges where your character is blindfolded. Which type of dice room you like the most? The 5 because there's no downside to it.
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I think d6 is the best for those who dare to play bad runs without holding r key down. 4 and 5 are by far the best ones but i guess room 4 since that one is always nice. Sometimes i don't need room 5. There are six different dice room configurations in the game, each corresponding with a face of a d6 and its own effect.
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It can be annoying to remember what each room does, but there are some handy signs that can act as reminders if you have the afterbirth+ expansion. Dice rooms are special rooms that can randomize many elements of the run. Dice rooms require two keys to be opened, unlike most other special rooms. For a dice room to spawn, two things must happen; First, the game must decide that a sacrifice room will spawn that floor.
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