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This can be used to quickly gain progress tied to the number of mom's heart kills. ) multiple times in one run. Dice rooms cost two keys to enter.
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If you have the repentance expansion installed, they will have red doors with a die above them. The screen will shake and the room's effect will resolve. They're a really clever way of somewhat solving the problem of shitty runs, sometimes rng just completely screws you over and a dice room has a good chance of making your build at least a little bit better. If i'm checking dice rooms, i'm pretty much exclusively looking for a 5 room.
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5 is always helpful unless you're trying to play fast (in which case you're probably not checking dice rooms), vs all the others being either highly situational or just straight up bad. Depending on the dice roll on the floor there is different effects. If you're having an amazing run and find a dice room that you don't know the effet of, i'd be careful, it may shuffle you to worse items. Dice rooms can be accessed through the use of two keys, and contain one of the 6 dice faces. Each room can only be used once, and each face has a different effect 1 pip rerolls isaac's currently held items, similarly to the d4 2 pips rerolls all pickups in the room itself, similarly to the d20