Faster, Better Biaryl Synthesis: The Power Of Lithium Exchange

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Jul 21, 2022 · herein, we report the flow microsynthesis of functionalized biaryls by integrating lithiation, zincation, and coupling reactions mediated by functionalized aryl zinc. Recent investigations revealed that microflow systems [13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26] serve as useful method for improving product selectivity in fast competitive.

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The Role of Conjugation in the Halogen−Lithium Exchange Selectivity

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