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Dice rooms have different effects depending on the number of pips. When you step on the die in the middle of the room, it activates the effect. You either got a 1 or a 6 pip room, which rerolls all your items.
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I usually do not like to use dice rooms unless i have a pretty bad kit going on, but if i have something that is doing work i usually just keep on keepin on. A dice room once gave me the leech buddy and the munched leaf. Which type of dice room you like the most? The 5 because there's no downside to it.
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I think d6 is the best for those who dare to play bad runs without holding r key down. 4 and 5 are by far the best ones but i guess room 4 since that one is always nice. Sometimes i don't need room 5. If you don't have enough keys, guppy's tail can leave you with a bunch of gold chests you can't open. Guppy's head is a good spacebar item, but if you have a ridiculously powerful one like the d6, then just pick up the head, use, reroll.