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Dice rooms are special rooms that can randomize many elements of the run. Dice rooms require two keys to be opened, unlike most other special rooms. For a dice room to spawn, two things must happen;

First, the game must decide that a sacrifice room will spawn that floor. This normally has a 1/7. This is the only item i know of that can break the game with no help from other items. All you need is a room full of pickups (see blank + dice shard for how to do that), and then a way to damage yourself.

Do you get different results based on the dots of the dice rooms

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You can do this an infinite number of times as long as you have teleports to attempt to break the game in your shop or secret room. With a d6 or dice shard, you can reroll all of these steam sales into other great items. (rerolls all held items, pickups, trinkets, and pedestal items) Crafting an active item destroys your current one and spawns new pickups (which i think still depend on the room you're in, so do this in the secret room for bone hearts). You could, for example, craft another portable slot and i think you know where this is going.

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