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First, the game must decide that a sacrifice room will spawn that floor. Once the game determines a sacrifice room will spawn, a dice room has a 1/50 (2%) chance to replace it. This chance increases to 27/125 (~22%) if isaac has two or more keys.
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I had *the* key, entered a dice room, lost *the* key, but still used it. [spoiler] so i grabbed the two key pieces needed to unlock mega satan's gate, and on another floor i lost it when i walked on a dice room (it was a one). Rock bottom, spindown dice, r key, sacred orb, mega mush, glitched crown, red key, the list goes on. Unfortunately, secret room items are also like.
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Dice rooms can be accessed through the use of two keys, and contain one of the 6 dice faces. 3 pips rerolls all pickups and trinkets for the entire floor. This includes shop pickups. 4 pips rerolls any item pedestals on the floor like the d6 would. 5 pips rerolls and restarts the current floor, which is the same effect as forget me now.
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